Retinoid Face-Off: Trifarotene vs. Adapalene vs. Tretinoin

Welcome to Skin Insights by YSBB.

Tripharotene, adapalene, tretinoin — what’s the difference, and which one should you choose?

These are all topical retinoids derived from vitamin A, but each has unique characteristics. Let’s break down the key differences so you can pick the best fit for your skin.

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1. Tretinoin – A high-efficacy classic for acne and aging

• The most extensively studied retinoid for acne, fine lines, and pigmentation.
• Available in various concentrations to suit different skin types.
• Also proven effective for smoothing skin texture and treating sun damage.
• Drawbacks: Higher irritation risk — dryness, peeling, and redness are common.
• Usage notes: Only at night. Must avoid sun exposure and cannot be combined with benzoyl peroxide.
• Domestic brands: TwoNT Cream (TheU Pharma), Stieva-A Cream (GSK, now discontinued)
• Recommended for: Resilient skin types seeking powerful results for both acne and aging.

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2. Adapalene – Acne-focused and gentle on sensitive skin

• Stable in light and oxygen, with lower irritation than tretinoin.
• Effective at clearing comedones (clogged pores) and preventing breakouts.
• Compatible with benzoyl peroxide — even available in combination formulas.
• Drawbacks: Less effective for wrinkles and pigmentation.
• Usage notes: Can be used in the morning or evening.
• Domestic brands: Differin Gel, Epiduo Forte (Galderma)
• Recommended for: Beginners or those with sensitive skin focused solely on acne treatment.

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3. Trifarotene – A new-generation retinoid for both face and body

• Newest fourth-generation retinoid with high selectivity and low irritation.
• Approved for use on the face and body — including chest and back acne.
• May improve acne scars and post-inflammatory pigmentation.
• Drawbacks: Limited evidence for anti-aging effects, and relatively high price point.
• Usage notes: Lightweight, non-greasy formula with high patient tolerance.
• Domestic brand: Aklief Cream (Galderma)
• Recommended for: Sensitive skin with acne on both face and body, especially if concerned with scarring and discoloration.

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Comparison at a Glance

• Skin Irritation: Tretinoin (High) / Adapalene (Moderate) / Trifarotene (Low)
• Acne Control: All three effective; adapalene excels in comedolytic action
• Anti-Aging: Tretinoin proven / Adapalene mild (only at 0.3%) / Trifarotene uncertain
• Scars & Pigmentation: Tretinoin & Trifarotene more effective
• Sun Sensitivity: Tretinoin (yes) / Adapalene (low) / Trifarotene (likely low)
• Use with Benzoyl Peroxide: Tretinoin (no) / Adapalene & Trifarotene (yes)
• Approved Ages: Tretinoin (12+) / Adapalene & Trifarotene (9+)
• Price Range: Tretinoin & Adapalene (affordable) / Trifarotene (premium)

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Tips for Choosing the Right One

• Sensitive skin with scarring concerns? Trifarotene may be the best fit.
• Looking for gentle, daily acne care? Start with adapalene.
• Need strong results for acne and signs of aging? Tretinoin is your go-to.

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Final Thoughts

Retinoids are among the most effective tools in dermatology — but success depends not just on the product you choose, but how you use it.

• Start every other night, using only a pea-sized amount.
• Apply to dry skin to minimize irritation.
• Use a gentle moisturizer and always wear sunscreen.

At YSBB Skin Clinic, we help you select the right retinoid and guide you through proper usage — so you can get results without unnecessary irritation.

Don’t navigate it alone. Let’s find the right formula for your skin.

YSBB Skin Clinic, Seoul, Korea